PeptAIDes

In collaboration with researchers from UC San Diego (CA, USA), the research team of Tim Hendrikx (Dept. of Laboratory Medicine, MUW, Vienna) has identified a novel mechanism that contributes to liver injury in progressive alcohol-associated liver disease. The study shows that secretion of IgA antibodies via the specialized polymeric immunoglobulin receptor (pIgR) in the liver is important to prevent bacterial translocation from the gut and protect against alcohol-induced liver damage. The results were recently published in the renowned journal „Gut“ (IF: 31.795).
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Tim Hendrikx, Sonja Lang, Dragana Rajčić, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl
http://dx.doi.org/10.1136/gutjnl-2022-328265

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