PeptAIDes

Our latest study ‚Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching‚ is online! Enjoy reading our article in the #Journal of Medicinal Chemistry.

An international consortium led by the PeptAIDes research team identified the peptide inhibitor of transendothelial T-cell migration (Pepitem) as a prototypic peptide with migration inhibition activity (read more about this topic in a comprehensive review article: Peptide modulators of cell migration: Overview, applications and future development). Using pepitem as a starting point and by developing the powerful structural scaffold matching approach, we generated the stabilized highly active probe VhTI-pep and showed its potency to reduce transendothelial migration of activated T-lymphocytes.

#structural scaffold matching, #pepitem, #transendothelial T-cell migration, #peptide drug design, #natural peptide drug development, #Medical University of Vienna

Link: Gattringer et al.