Tropical psychotria plants are a richsource for peptide inhibitors of human prolyloligopeptidase
A new research article was published in the Journal Natural Products and Bioprospecting (IF 2024: 4.9). Hellinger et al. report the screening of eleven Psychotria species for cyclic cystine-knot peptides. Psysol 3 from Psychotria solitudinum was isolated as a prototypic inhibitor of human prolyl oligopeptidase. The synthetic peptide showed an IC50 = 1.3 µM and is thus one of the most active cyclotides known so far inhibiting the enzyme.
PeptAIDes 