PI Dr. Roland Hellinger was invited to give an oral presentation at the 2nd Blood-Brain-Barrier Barcelona Conference with around +150 attendees. The title of the talk was „BLOOD BRAIN BARRIER – NATURAL PEPTIDE SHUTTLES FOR DRUG DELIVERY INTO THE CNS“.
My special thank you is directed to funders, e.g., EU COST Action Snoopy and EU Cost Action OneHealthDrugs, for providing STSM mobility support to involved researchers.
My research stay at the EPFL between 01/06/2025 and 31/08/2025 is coming to an end. I had a wonderful stay hosted by Univ.-Prof. Christian Heinis and the Laboratory for Protein and Peptide Therapeutics (LPPT). The SNOOPY COST action CA23111 provided me with financial support through a short-time scientific mission (STSM), for which I am deeply grateful.
Our latest study ‚Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching‚ is online! Enjoy reading our article in the #Journal of Medicinal Chemistry.
An international consortium led by the PeptAIDes research team identified the peptide inhibitor of transendothelial T-cell migration (Pepitem) as a prototypic peptide with migration inhibition activity (read more about this topic in a comprehensive review article: Peptide modulators of cell migration: Overview, applications and future development). Using pepitem as a starting point and by developing the powerful structural scaffold matching approach, we generated the stabilized highly active probe VhTI-pep and showed its potency to reduce transendothelial migration of activated T-lymphocytes.
#structural scaffold matching, #pepitem, #transendothelial T-cell migration, #peptide drug design, #natural peptide drug development, #Medical University of Vienna
Link: Gattringer et al.
Roland Hellinger, Austrian representative and member of the management committee, participated in the COST Snoopy conference in Cres (Croatia), which took place from the 15th to 17th June 2025.
Cost CA23111 – Searching for Nanostructured or pOre fOrming Peptides for therapY is a European-wide network focusing on solutions and networking in this field.
Roland Hellinger contributed an oral presentation to the OHD 2025 conference, „Strategies for breaking the chain between the parasite reservoir in animals and infections in humans“, which was held in Antwerp (Belgium) from 04-06th June. The talk was titled ‚Discovery, characterization and application of nature-derived cystine-knot peptides with antimicrobial activity‘.
The cost action OHD is a 3rd year project focusing on drug development against vector-borne diseases.
PeptAIDes 