PI Dr. Hellinger as well as colleagues Paula Schwarz and Jonathan Dieringer attended the XIX Iberian Peptide Symposium in Santiago de Compostela in Spain (26.02.-01.03.2025). Roland Hellinger gave an oral presentation of the ZK relevant study ‚Scaffold selection and design of a migration inhibitor peptide‘. Schwarz and Dieringer presented their study progress with a scientific poster.
Here is the link to the conference information.
The research consortium, wit the scientists Roland Hellinger, Kirtikumar Jadhav, Jasmin Gattringer and Paula Schwarz, attended the 37th European Peptide Symposium and the 12th International Peptide Conference in Florence from 24-30th August. The project work of several projects was presented in a total of five posters. Advisory Board Members, DR. Christian W. Gruber and Dr. Markus Muttenthaler gave excellent oral talks.
A PhD position is vaccant in the laboratory of Dr. Roland Hellinger. Further information can be received via this link:
https://www.fwf.ac.at/aktuelles/jobboerse/jobdetail/phd-position-in-peptide-pharmacology
Applications are accepted sent to roland.hellinger@meduniwien.ac.at no later than 30th September 2024. Your message of interest is accompanied by a curriculum vitae (surename_CV) and a max. 1-page motivation letter (surname_letter). The contact information of two referees/supervisors shall be provided as well. The position is filled as soon as possible, only holders of a Master-/Diploma certificate may apply, no applications from non-graduated students shall be accepted.Applications will be evaluated on a rolling basis in a multi stage procedure.
A research paper, entitled ‚Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide‚, was published in the Elsevier Journal of Biomedicine & Pharmacotherapy [IF 6.9, Top 5% in Pharm. & Pharmacy].
Here is the link to online version of the article: https://doi.org/10.1016/j.biopha.2024.117057.
In this research, plant extracts were found to increase the effectiveness of cytotoxic NK cells. The compound caripe 8, derived from Carapichea ipecacuanha, enhanced the function of both mouse and human NK cells, leading to tumor cell death. The authors observed that caripe 8 directly activated NK cells to induce tumor cell death.
List J, Gattringer J, Huszarek S, Marinovic S, Neubauer H, Kudweis P, Putz EM, Hellinger R.*, Gotthardt* G, Boosting the anti-tumor activity of natural killer cells by caripe 8 – a Carapichea Ipecacuanha isolated cyclotide. Biomed Pharmacother, 2024;177,117057. doi: https://doi.org/10.1016/j.biopha.2024.117057. * equally contributing corresponding authors.
Roland Hellinger carries out a three-month mobility program at the Ecole Polytechnique fédérale de Lausanne (EPFL) during 01.06. to 31.08.2024. Assoc. Prof. Dr. Christian Heinis, head of the laboratory for protein and peptide therapeutics (LPPT), will host the guest researchers visit. During the mobility, Roland will work on novel peptide libraries targeting a protease target.
PeptAIDes 