An interdisciplinary team reported on the design of natural peptide derived cyclic BBB shuttles. In ‚Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery‘ , published in the Journal of Biom. & Pharmacotherapy (IF 7.5), we show that natural peptide are scaffolds for design of novel BBB…
A new research article was published in the Journal Natural Products and Bioprospecting (IF 2024: 4.9). Hellinger et al. report the screening of eleven Psychotria species for cyclic cystine-knot peptides. Psysol 3 from Psychotria solitudinum was isolated as a prototypic inhibitor of human prolyl oligopeptidase. The synthetic peptide showed an IC50 = 1.3 µM and…
The Austrian Science Fund (FWF) project ZK-81B, PeptAIDes- Peptide Therapeutics for Autoimmune and Inflammtory Diseases officially ended with the 30.09.2025. The project’s final report is know available via the Science Radar provided by the Austrian Science Fund. Over the past five years, the interdisciplinary Young Independent Researcher Group PeptAIDes has worked on fundamental questions in…
A new research article was recently published in the Journal of Natural Products (ACS). Akinleye, et al. investigated the expression of cyclic cystine-knot peptides in Spgelia anthelmia L. and studied their antimicrobial activity.
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PeptAIDes 