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Natural circular peptide inbhibitors of human prolyl oligopeptidase modulate caspase signalling in T-cells

Here is the link to the publication! Jonathan Dieringer, Paula Schwarz, Kirtikumar B. Jadhav, Andreas Fraunhofer, Tobias Gökler, Anne C. Conibear, Christian W. Gruber, Roland Hellinger, Natural circular peptides regulate T-lymphocyte proliferation by inhibiting prolyl oligopeptidase, Biomedicine & Pharmacotherapy, 2026, 204, 120017; https://doi.org/10.1016/j.biopha.2026.120017.

Publication on Alcohol intake reprograming of hepatic immune-metabolic circuits

The interdisciplinary team led by Tim Hendrikx (Principial Investigator) and Constanze Höbinger (First author) from the Department of Laboratory Medicine of the Medical Universtiy of Vienna published their study „Alcohol intake reprograms hepatic immune-metabolic circuits to exacerbate murine atherosclerosis and human cardiovascular risk“ in the Journal of JHEP Reports: Innovation in Hepatology (IF 8.7:2025). Here…

Science communication

I am happy to let you know that I am supporting the Science Communication activities of the Austrian Exchange Service (OeAD). As Science Ambassador I am willing to visit interested schools in person to hold thematic workshops with kids.

New publication on the design of cyclic peptide BBB shuttles.

An interdisciplinary team reported on the design of natural peptide derived cyclic BBB shuttles. In ‚Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery‘ , published in the Journal of Biom. & Pharmacotherapy (IF 7.5), we show that natural peptide are scaffolds for design of novel BBB…

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