Open PhD position

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A PhD position is vaccant in the laboratory of Dr. Roland Hellinger. Further information can be received via this link:

https://www.fwf.ac.at/aktuelles/jobboerse/jobdetail/phd-position-in-peptide-pharmacology

Applications are accepted sent to roland.hellinger@meduniwien.ac.at no later than 30th September 2024. Your message of interest is accompanied by a curriculum vitae (surename_CV) and a max. 1-page motivation letter (surname_letter). The contact information of two referees/supervisors shall be provided as well. The position is filled as soon as possible, only holders of a Master-/Diploma certificate may apply, no applications from non-graduated students shall be accepted.Applications will be evaluated on a rolling basis in a multi stage procedure.

Enhancing NK Cells Anti-Tumor Activity with Caripe 8 from Carapichea Ipecacuanha

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A research paper, entitled ‚Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide‚, was published in the Elsevier Journal of Biomedicine & Pharmacotherapy [IF 6.9, Top 5% in Pharm. & Pharmacy].
Here is the link to online version of the article: https://doi.org/10.1016/j.biopha.2024.117057.

In this research, plant extracts were found to increase the effectiveness of cytotoxic NK cells. The compound caripe 8, derived from Carapichea ipecacuanha, enhanced the function of both mouse and human NK cells, leading to tumor cell death. The authors observed that caripe 8 directly activated NK cells to induce tumor cell death.

List J, Gattringer J, Huszarek S, Marinovic S, Neubauer H, Kudweis P, Putz EM, Hellinger R.*, Gotthardt* G, Boosting the anti-tumor activity of natural killer cells by caripe 8 – a Carapichea Ipecacuanha isolated cyclotide. Biomed Pharmacother, 2024;177,117057. doi: https://doi.org/10.1016/j.biopha.2024.117057. * equally contributing corresponding authors.

Caripe 8 enhances NK cell cytotoxicity toward target cells.

A new phytocannabinoid peptide has been disovered in Viola.

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A research team led by Christian Gruber from MedUni Vienna and supported by the PeptAIDes team has discovered a new phytocannabinoid in sweet violet plants (Viola odorata). The peptide interacts with a specific receptor that does not trigger psychoactive effects and, due to its molecular properties, could spark the research and development of novel drugs for the treatment of autoimmune diseases, pain, or chronic inflammation. The results of the study were recently published in the „Journal of Biological Chemistry.“.

More can be read using these links:

https://www.meduniwien.ac.at/web/en/about-us/news/2024/news-in-april-2024/new-phytocannabinoid-discovered-in-sweet-violet

Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor.
Nataša Tomašević, Fabiola Susanna Emser, Edin Muratspahić, Jasmin Gattringer, Simon Hasinger, Roland Hellinger, Peter Keov, Manuel Felkl, Jürg Gertsch, Christian F.W. Becker and Christian W. Gruber.
DOI: 10.1016/j.jbc.2024.107330

Conference Visit: International Peptide Conference 2023

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Our research group attended the 13th International Peptide Symposium and 15th Australian Peptide Conference held in Brisbane, Australia from October 15th to 20th. We were delighted to be a part of the fantastic scientific program that was organized. The event featured several presentations by our researchers, including a Rapid Fire talk given by Jasmin Gattringer, and three poster presentations by the PeptAIDes team. Furthermore, the Peptidomics and Drug Discovery research group contributed to the event with an oral presentation by Dr. Christian Gruber and another poster presentation. We acknowledge that Dr. Markus Muttenhaler, a member of our PeptAIDes advisory board, was honored with the prestigious Tregear Award by the Australian Peptide Society for his long-lasting contributions to the field of peptide science.

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