The Austrian Science Funds (FWF) granted TWO stand alone projects to ZK principal investigators. Tim Hendrikx received €404K the project P 36774 ‚IgE: Ein neues Target um Alkoholische Fettleber zu behandeln‘ and Roland Hellinger received €422K for the project P 36736 ‚Psysol 2 als neuartiges Modulator für Prolyl Oligopeptidase‘.
Roland Hellinger carries out a 33 day Erasmus+ staff mobility research visit at the PREP laboratory of Prof. Dr. Timo Myöhänen from the University of Eastern Finland.
Jasmin Gattringer, Christian W. Gruber and Roland Hellinger published a review article in Drug Discovery Today on peptide cell migration inhibitors.
The article is available here.
Gattringer J, Gruber CW, Hellinger R. Peptide modulators of cell migration: Overview, applications and future development. Drug Discov Today. 2023 Mar 13:103554. doi: 10.1016/j.drudis.2023.103554. PMID: 36921670.
Eva-Maria Zangerl-Plessl (Principal Iinvestigator) first authored a peer review publication in Frontier in Molecular Biosciences (IF 4.6). The title of the work is ‚Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate‘.
The article is downloadable on the publishers website and here doi.org/10.3389/fmolb.2023.1137368.
In collaboration with researchers from UC San Diego (CA, USA), the research team of Tim Hendrikx (Dept. of Laboratory Medicine, MUW, Vienna) has identified a novel mechanism that contributes to liver injury in progressive alcohol-associated liver disease. The study shows that secretion of IgA antibodies via the specialized polymeric immunoglobulin receptor (pIgR) in the liver is important to prevent bacterial translocation from the gut and protect against alcohol-induced liver damage. The results were recently published in the renowned journal „Gut“ (IF: 31.795).
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Tim Hendrikx, Sonja Lang, Dragana Rajčić, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl
http://dx.doi.org/10.1136/gutjnl-2022-328265
See also news feed of the MUW.
PeptAIDes 