Nature Reviews Methods Primers: Peptidomics

In recent collaborative work, our team reviewed the research field ‚Peptidomics‘ in a Nature Reviews Methods Primers article.

‚Peptidomics, the comprehensive qualitative and quantitative analysis of all peptides in a biological sample, is an emerging field derived from proteomics and enabled by modern separation, analytical and computation technologies. … This review describes applications of peptidomics and modern approaches for peptide extraction, fractionation, detection, quantification, functional annotation, and structural prediction.‚ (Hellinger R et al. 2023).

Hellinger R., Sigurdsson A., Wu W., Romanova EV., Li L., Sweedler JV., Süssmuth RD., Gruber CW. Peptidomics. 2023. Nat Rev Methods Primers, 3, 25. https://doi.org/10.1038/s43586-023-00205-2.

Austrian Science Funds grants projects to ZK principal investigators.

The Austrian Science Funds (FWF) granted TWO stand alone projects to ZK principal investigators. Tim Hendrikx received €404K the project P 36774 ‚IgE: Ein neues Target um Alkoholische Fettleber zu behandeln‘ and Roland Hellinger received €422K for the project P 36736 ‚Psysol 2 als neuartiges Modulator für Prolyl Oligopeptidase‘.

Peptide modulators of cell migration: Overview, applications and future development

Jasmin Gattringer, Christian W. Gruber and Roland Hellinger published a review article in Drug Discovery Today on peptide cell migration inhibitors.

The article is available here.

Gattringer J, Gruber CW, Hellinger R. Peptide modulators of cell migration: Overview, applications and future development. Drug Discov Today. 2023 Mar 13:103554. doi: 10.1016/j.drudis.2023.103554. PMID: 36921670.

All-atom molecular dynamics simulations of the hERG1 channel 

Eva-Maria Zangerl-Plessl (Principal Iinvestigator) first authored a peer review publication in Frontier in Molecular Biosciences (IF 4.6). The title of the work is ‚Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate‘.

The article is downloadable on the publishers website and here doi.org/10.3389/fmolb.2023.1137368.

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