ProPeptide Research Laboratory

Who We Are?

We are Peptide Architects. We design & construct peptides and proteins to tinker with biology. Simply put, we specialize in ProPeptide chemical biology and medicinal chemistry to drive innovation and engage both experts and non-experts alike.

Principal Investigator – Kirtikumar B Jadhav

Our Scientific Pursuits

  Piet Mondriaan    

Peptide-Protein Technologies: We specialize in creating innovative tools to simplify the production of peptides and proteins. Our goal is to streamline complex processes, making peptide and protein research faster, more efficient, and eco-friendly.

  • Our Inspiration: Piet Mondrian taught us that art can emerge from the simplicity of lines and primary colors. Inspired by this, we strive to bring simplicity to peptide production technologies, empowering non-chemists to create these molecules. By broadening access, we aim to benefit both science and society.

Designer amino acids – from Peptides to synthetic biology: Imagine if we could redesign the building blocks of life. That’s what we do with designer amino acids. These specially crafted molecules allow us to control the synthesis of peptides and proteins, influencing biological functions at their core. This precise control opens new possibilities in synthetic biology, where we can create entirely new biological systems or enhance existing ones with purpose and accuracy.

Our inspiration: Leonardo da Vinci’s “fantastic dragon” inspires us, as he crafted a captivating beast by combining the necessary parts from different animals—lizards, serpents, butterflies, bats, and other creatures. Drawing from this creativity, we create designer amino acids by integrating essential features needed to achieve multiple desired chemical functions. We design and synthesize precursor amino acids that possess more than one function and can be activated to perform specific tasks in response to given signals.

  
Da Vinci    
Title: Study of Dragon
Michael Angelo    
Title: David and hand of God

Peptide-Based Drug Discovery: Peptides, short chains of amino acids, are at the heart of our work in drug discovery. We’re developing new ways to use these molecules to accelerate the discovery of life-saving drugs. Our goal is not only to speed up drug discovery but also to make the process eco-friendly and cost-effective, helping bring new treatments to patients while minimizing environmental impact.

Our inspiration: Michelangelo’s iconic painting „The Creation of Adam“ inspires us, drawing a parallel between the divine connection depicted in the artwork and the union of small molecules and peptides in drug discovery, representing Adam and God reaching out to each other. Just as this moment symbolizes the fusion of life and creation, we believe in harnessing the power of small molecules and peptides to bridge the gap between science and healing. Our vision is to develop innovative strategies that accelerate the discovery of life-saving drugs, taking the best of both worlds.

Principal Investigator

Kirtikumar B Jadhav studied pharmacy at University of Pune, Maharashtra, India and specialised in medicinal chemistry during his masters study at the National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Chandigarh (India). Subsequently, he joined a pharmaceutical company – Ranbaxy research laboratories, Ltd., Gurgaon (New Delhi), India as a Research Associate and designed and synthesized carbocyclic, heterocyclic & spiroheterocyclic peptidomimetics (multistep synthesis: 11-18 steps) as reversible inhibitors for Caspase I for treatment of Rheumatoid arthritis. Subsequently, he did his doctoral studies under the supervision of Prof. Dr. Hans-Dieter Arndt at Max Planck Institute for molecular physiology, Dortmund and Friedrich Schiller University Jena, Germany. Here, he explored proteolytically stable antibacterial D-/L-peptides libraries, their foldameric properties by generating dynamic combinatorial libraries, developed chemo-selective method to access disulfide containing complex natural products and elucidated a structure of a novel D-/L-peptide kolossin A by total and library synthesis. Afterwards, he moved on to the Stockholm University, Stockholm, Sweden as a postdoctoral fellow to work on templated protein ligations. Then he joined neuropeptide group of Dr. Markus Muttenthaler as a senior postdoctoral researcher at University of Vienna. Since 2019, he is a Principal Investigator at the Institute of Biological Chemistry at the University of Vienna.

Our research tools

  • Peptide-protein technologies
    • Solid phase peptide synthesis
    • Native-/Expressed protein ligations
    • Recombinant protein synthesis
  • Designer Amino acids
    • Multistep organic synthesis
    • Peptide foldamers, molecular recognition
    • Biomimicry
    • Synthetic Biology
    • Peptide natural products
  • Drug discovery
    • Peptidomimetics, peptides, small molecule-peptide conjugates, Disulfide rich cyclic peptides
    • Structure activity relationships
    • Dynamic combinatorial chemistry