Schlagwort-Archiv: PeptAIDes

New publication on the design of cyclic peptide BBB shuttles.

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An interdisciplinary team reported on the design of natural peptide derived cyclic BBB shuttles. In ‚Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery‘ , published in the Journal of Biom. & Pharmacotherapy (IF 7.5), we show that natural peptide are scaffolds for design of novel BBB shuttle probes using computational prediction-informed peptide molecular grafting. The sunflower trypsin inhibitor-1 scaffold was used as prototype and probes generated that incorporated reported BBB shuttle sequences of different size, conformation and amino acid composition. The probe L2-peptide 22 was selected for in vitro characterization and was applied in a rat CNS transprot model.

The full citation: Schwarz P., Dieringer J. Jadhav BK., Lucana M., Ginosyan A., Oller-Salvia B., Gruber CW., Loryan I.,* and Hellinger R.,* Design of sunflower trypsin inhibitor 1 derived probes targeting the LDLR and evaluation of their brain delivery, 2026 Biomed. and Pharmacoth., 202:119756; https://doi.org/10.1016/j.biopha.2026.119756

Enhancing NK Cells Anti-Tumor Activity with Caripe 8 from Carapichea Ipecacuanha

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A research paper, entitled ‚Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide‚, was published in the Elsevier Journal of Biomedicine & Pharmacotherapy [IF 6.9, Top 5% in Pharm. & Pharmacy].
Here is the link to online version of the article: https://doi.org/10.1016/j.biopha.2024.117057.

In this research, plant extracts were found to increase the effectiveness of cytotoxic NK cells. The compound caripe 8, derived from Carapichea ipecacuanha, enhanced the function of both mouse and human NK cells, leading to tumor cell death. The authors observed that caripe 8 directly activated NK cells to induce tumor cell death.

List J, Gattringer J, Huszarek S, Marinovic S, Neubauer H, Kudweis P, Putz EM, Hellinger R.*, Gotthardt* G, Boosting the anti-tumor activity of natural killer cells by caripe 8 – a Carapichea Ipecacuanha isolated cyclotide. Biomed Pharmacother, 2024;177,117057. doi: https://doi.org/10.1016/j.biopha.2024.117057. * equally contributing corresponding authors.

Caripe 8 enhances NK cell cytotoxicity toward target cells.

Research retreat 2023

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The ZK-81B project staff met recently for the research retreat in 2023. Neusiedl am See provided a wonderful environment for our event. Up to thirteen young researchers or principal investigators gathered together to hear from the lastest research progress within the PeptAIDes program and to discuss next experiments or the overall strategy. Socializing did not came to short as we used a sunny afternoon to have a bicycle tour to Podersdorf.