PeptAIDes

A research paper, entitled ‚Boosting the anti-tumor activity of natural killer cells by caripe 8 – A Carapichea ipecacuanha isolated cyclotide‚, was published in the Elsevier Journal of Biomedicine & Pharmacotherapy [IF 6.9, Top 5% in Pharm. & Pharmacy].
Here is the link to online version of the article: https://doi.org/10.1016/j.biopha.2024.117057.

In this research, plant extracts were found to increase the effectiveness of cytotoxic NK cells. The compound caripe 8, derived from Carapichea ipecacuanha, enhanced the function of both mouse and human NK cells, leading to tumor cell death. The authors observed that caripe 8 directly activated NK cells to induce tumor cell death.

List J, Gattringer J, Huszarek S, Marinovic S, Neubauer H, Kudweis P, Putz EM, Hellinger R.*, Gotthardt* G, Boosting the anti-tumor activity of natural killer cells by caripe 8 – a Carapichea Ipecacuanha isolated cyclotide. Biomed Pharmacother, 2024;177,117057. doi: https://doi.org/10.1016/j.biopha.2024.117057. * equally contributing corresponding authors.