Research output | PeptAIDes

Kategorie-Archiv: Research output

A new phytocannabinoid peptide has been disovered in Viola.

Veröffentlicht am 30. April 2024 von Roland Hellinger Hinterlasse einen Kommentar

A research team led by Christian Gruber from MedUni Vienna and supported by the PeptAIDes team has discovered a new phytocannabinoid in sweet violet plants (Viola odorata). The peptide interacts with a specific receptor that does not trigger psychoactive effects and, due to its molecular properties, could spark the research and development of novel drugs for the treatment of autoimmune diseases, pain, or chronic inflammation. The results of the study were recently published in the „Journal of Biological Chemistry.“.

Nature Reviews Methods Primers: Peptidomics

Veröffentlicht am 30. März 2023 von Roland Hellinger Hinterlasse einen Kommentar

In recent collaborative work, our team reviewed the research field ‚Peptidomics‘ in a Nature Reviews Methods Primers article.

‚Peptidomics, the comprehensive qualitative and quantitative analysis of all peptides in a biological sample, is an emerging field derived from proteomics and enabled by modern separation, analytical and computation technologies. … This review describes applications of peptidomics and modern approaches for peptide extraction, fractionation, detection, quantification, functional annotation, and structural prediction.‚ (Hellinger R et al. 2023).

Hellinger R., Sigurdsson A., Wu W., Romanova EV., Li L., Sweedler JV., Süssmuth RD., Gruber CW. Peptidomics. 2023. Nat Rev Methods Primers, 3, 25. https://doi.org/10.1038/s43586-023-00205-2.

Research output

Peptide modulators of cell migration: Overview, applications and future development

Veröffentlicht am 21. März 2023 von Roland Hellinger Hinterlasse einen Kommentar

Jasmin Gattringer, Christian W. Gruber and Roland Hellinger published a review article in Drug Discovery Today on peptide cell migration inhibitors.

The article is available here.

Gattringer J, Gruber CW, Hellinger R. Peptide modulators of cell migration: Overview, applications and future development. Drug Discov Today. 2023 Mar 13:103554. doi: 10.1016/j.drudis.2023.103554. PMID: 36921670.

Research output

All-atom molecular dynamics simulations of the hERG1 channel

Veröffentlicht am 24. Februar 2023 von Roland Hellinger Hinterlasse einen Kommentar

Eva-Maria Zangerl-Plessl (Principal Iinvestigator) first authored a peer review publication in Frontier in Molecular Biosciences (IF 4.6). The title of the work is ‚Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate‘.

The article is downloadable on the publishers website and here doi.org/10.3389/fmolb.2023.1137368.

Research output

Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice

Veröffentlicht am 24. Januar 2023 von Roland Hellinger Hinterlasse einen Kommentar

In collaboration with researchers from UC San Diego (CA, USA), the research team of Tim Hendrikx (Dept. of Laboratory Medicine, MUW, Vienna) has identified a novel mechanism that contributes to liver injury in progressive alcohol-associated liver disease. The study shows that secretion of IgA antibodies via the specialized polymeric immunoglobulin receptor (pIgR) in the liver is important to prevent bacterial translocation from the gut and protect against alcohol-induced liver damage. The results were recently published in the renowned journal „Gut“ (IF: 31.795).
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Tim Hendrikx, Sonja Lang, Dragana Rajčić, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl
http://dx.doi.org/10.1136/gutjnl-2022-328265