Eva-Maria Zangerl-Plessl (Principal Iinvestigator) first authored a peer review publication in Frontier in Molecular Biosciences (IF 4.6). The title of the work is ‚Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate‘.
The article is downloadable on the publishers website and here doi.org/10.3389/fmolb.2023.1137368.
In collaboration with researchers from UC San Diego (CA, USA), the research team of Tim Hendrikx (Dept. of Laboratory Medicine, MUW, Vienna) has identified a novel mechanism that contributes to liver injury in progressive alcohol-associated liver disease. The study shows that secretion of IgA antibodies via the specialized polymeric immunoglobulin receptor (pIgR) in the liver is important to prevent bacterial translocation from the gut and protect against alcohol-induced liver damage. The results were recently published in the renowned journal „Gut“ (IF: 31.795).
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Tim Hendrikx, Sonja Lang, Dragana Rajčić, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl
http://dx.doi.org/10.1136/gutjnl-2022-328265
See also news feed of the MUW.
Researchers at MedUni Vienna, Karl Landsteiner University of Health Sciences, University of Veterinary Medicine Vienna and Ludwig Boltzmann Institute for Cancer Research demonstrate an anti-tumor effect of certain nature-derived cyclic peptides.
Link to the news feed of the Medical University of Vienna.
The publication is online available : Biomedicine & Pharmacotherapy
J. Lind, R. Hellinger, P. Kudweis, H. P. Moll, J. Gattringer, K. Thell, S. Edtmayer, C. W. Gruber, D. Stoiber, K. Kollmann.
The nature inspired peptide [T20K]-kalata B1 induces anti-tumor effects in anaplastic large cell lymphoma
DOI: https://doi.org/10.1016/j.biopha.2022.113486
The researchers Eva-Maria Zangerl-Plessl (PI) and Theres Friesacher (PhD student) have contributed to the research article ‚β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis‘. The study was peer reviewed and published by Communications in Biology (IF 6.5, Nature Publishing Group) and is availably onlin here.
The researchers Negar Sadeghi Hassanabadi and PI Dagmar Gotthardt discussed the role of innate lymphoid cells in Multiple Sclerosis in a peer review article. The work was published by Frontiers in Immunology and is available online here.
PeptAIDes 