PeptAIDes

In collaboration with researchers from UC San Diego (CA, USA), the research team of Tim Hendrikx (Dept. of Laboratory Medicine, MUW, Vienna) has identified a novel mechanism that contributes to liver injury in progressive alcohol-associated liver disease. The study shows that secretion of IgA antibodies via the specialized polymeric immunoglobulin receptor (pIgR) in the liver is important to prevent bacterial translocation from the gut and protect against alcohol-induced liver damage. The results were recently published in the renowned journal „Gut“ (IF: 31.795).
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Tim Hendrikx, Sonja Lang, Dragana Rajčić, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl
http://dx.doi.org/10.1136/gutjnl-2022-328265

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The researchers Eva-Maria Zangerl-Plessl (PI) and Theres Friesacher (PhD student) have contributed to the research article ‚β subunits of GABA_A receptors form proton-gated chloride channels: Insights into the molecular basis‘. The study was peer reviewed and published by Communications in Biology (IF 6.5, Nature Publishing Group) and is availably onlin here.

The researchers Negar Sadeghi Hassanabadi and PI Dagmar Gotthardt discussed the role of innate lymphoid cells in Multiple Sclerosis in a peer review article. The work was published by Frontiers in Immunology and is available online here.

The research network around the principal investigator Tim Hendrikx (Department of Laboratory Medicine, KILM, Medical University Vienna, Vienna, Austria) published the study with the title ‚Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH.‚ The article has been been made online available by the Journal of Hepatology (IF 30.08)!) which is a TOP journal within the 5% in the field of GASTROENTEROLOGY & HEPATOLOGY.